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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) in excess of 27, provided that they also are afflicted by weight-related medical issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had an average weight loss of four years old.1% instead of participants who were given placebos) after a 12- month period, while a separate study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to shed pounds can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people that go through it one should err on the side of caution and allow the FDA do its job and demand some investigation be done so that the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to earn money and that they would say almost anything to keep people on their own medications.

Researchers found out that participants using this drug for a year, lost weight within 4 weeks and have kept the body weight off during the entire 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which might be made up of several active ingredient, which can make them more effective and safer.

Combo-pilling may be the newest fad or also the newest ahead under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular could be the fact that at the time of right now there aren't long term prescription diet pills that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are actually rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in people with seizure disorders. The drug may also raise hypertension and pulse rate, and really should not be used in those with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must stop used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients towards the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

The most common side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.